Peter: You know, someday they’re going to find a way to bottle the strength of the Parker women… and on that day… the criminals of the world better look out.
A former classmate of Peter’s has a laboratory accident that gives him superpowers, and he blames him for it. He tries to hurt Aunt May and Mary Jane as revenge by setting both their houses on fire, but they are unharmed. May is quiet and Peter thinks she hates him for not stopping the destruction of her house and is upset and broken over it, but MJ takes charge and comforts him, and all Aunt May wanted was a few minutes to retrieve a family photo album that was in the debris. In the face of adversity, the Parker women are stronger than Spider-Man himself.
Amazing Spider-Man #519